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WitrynaBioss Anti-HECT E3 ubiquitin ligase Polyclonal, Catalog # BS-15445R. Tested in Western Blot (WB), Immunocytochemistry (ICC/IF), Immunohistochemistry (Frozen) (IHC (F)), Immunohistochemistry (Paraffin) (IHC (P)) and ELISA (ELISA) applications. ... HERC5 (E3 ISG15 - protein ligase HERC5) is a major E3 ligase for ISG15 … WitrynaHERC5 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 367 amino acids (681-1024 a.a.) and having a molecular mass of 43kDa. HERC5 is fused to a 23 amino acid His-tag at N-terminus.

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WitrynaHERC5 is a protein with a HECT domain and 5 RCC1 repeats. The HERC5 protein localizes to the cytoplasm and perinuclear region and serves as an INF-induced E3 protein ligase that mediates ISGylation of protein targets. HERC5 exhibits antiviral activity towards HIV-1, influenza A virus and human papillomavirus. HERC5 is a major E3 … WitrynaConversely, HERC5 coexpression with Ube1L and UbcH8 induces the ISG15 conjugation in vivo independent of IFN stimulation. A targeted substitution of Cys-994 to Ala in the … irish kennedy tartan fabric

HERC5 is an IFN-induced HECT-type E3 protein ligase that

Witryna26 sty 2024 · HECT and RLD domain containing E3 ubiquitin protein ligase 5 (HERC5), a protein with a ligand role, activates the chemotaxis and the local infiltration with T lymphocytes, being considered a biomarker for predicting HCC recurrence, as well as the poor survival rates even for early stage HCC (13,14). In this scenario, we aimed to … WitrynaHERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 HIBCH 3-hydroxyisobutyryl-CoA hydrolase HIST1H1C histone cluster 1, H1c HIST1H2BG histone cluster 1, H2bg HIST1H4C ... Witryna15 wrz 2004 · The C-termini of HERC5 and E6-AP are homologous and both proteins contain a HECT-domain, characteristic of E3 ubiquitin ligases. In contrast to RING … port 8201 was already in use

The significance of and genes expression in resistance to cytotoxic ...

Functional and pathological relevance of HERC family ... - Springer

Witryna17 sty 2012 · Type I interferon (IFN) stimulates expression and conjugation of the ubiquitin-like modifier IFN-stimulated gene 15 (ISG15), thereby restricting replication of a wide variety of viruses. Conjugation of ISG15 is critical for its antiviral activity in mice. HECT domain and RCC1-like domain containing protein 5 (HerC5) mediates global … Witryna8 lut 2024 · Among them, HERC5/TAC1 interacted and GAS5 docked well with HERC5. Conclusion . The lncRNA GAS5 in the peripheral blood exosomes in patients with GDM may be a new target for the detection of GDM, and the interaction between GAS5 and HERC5/TAC1 may be involved in the pathogenesis of GDM. ... B. R. Binder, and J. … port 8888 is in useWitrynaHERC5 (E3 ISG15 - protein ligase HERC5) is a major E3 ligase for ISG15 conjugation. It acts a positive regulator of innate antiviral response in cells induced by interferon. HERC5 functions as a part of the ISGylation machinery that recognizes target protein in a broad and relatively non-specific manner. irish kennel club puppies

"Witryna19 sie 2024 · The homologous to E6AP C-terminus (HECT) domain and RCC1-like domain-containing (HERC) proteins can function as tumour suppressors and as … " - Herc5 hect

Herc5 hect

HECT E3s and human disease BMC Biochemistry Full Text

http://www.toxicolres.org/journal/view.html?doi=10.5487/TR.2024.33.3.211 Witryna10 lip 2024 · Targeting one of these proteins by a HECT E3 ubiquitin ligase and its degradation modulates apoptosis. Other HECT E3 ubiquitin ligases have, for example, antiviral activities: one of them, HERC5, inhibits the replication of influenza A virus. Dysfunction of HECT E3 ubiquitin ligase is associated with neurodegenerative disorders.

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Witryna(d) entering the normalized gene expression values into one or more acute respiratory illness classifiers selected from a bacterial acute respiratory infection (ARI) classifier, a Witryna9 cze 2024 · 4. HERC5: A Unique HECT E3 Ubiquitin Ligase That ISGylates Viral Proteins. HERC5 is a multidomain 114 kDa protein that belongs to both the HECT E3 ubiquitin ligase family and the RCC1 superfamily . To date, 28 HECT E3 ubiquitin ligases have been identified in humans, with each having a conserved HECT domain found …

WitrynaInterferon (IFN) is a crucial first line of defense against viral infection. This cytokine induces the expression of several IFN-Stimulated Genes (ISGs), some of which act as restriction factors. Upon IFN stimulation, cells also express ISG15 and Witryna18 maj 2010 · E3 ISG15--protein ligase HERC5. Gene. HERC5. Status. UniProtKB reviewed (Swiss-Prot) Organism. Homo sapiens (Human) Amino acids. 1024. Protein …

WitrynaHECT and RCC1-containing protein 5 (HERC5) and interferon-stimulated gene 15 (ISG15) are two antiviral immune proteins that are induced following IFN- / signal transduction. Multiple studies have established that HERC5 plays a central role in mam-malian innate immunity by ISGylating viral proteins to disrupt viral replication [26,27]. Witryna14 mar 2024 · Besides, HECT and RLD domain containing E3 ubiquitin protein ligase 5 (HERC5), Interferon induced protein with tetratricopeptide repeats 2(IFIT2), Interferon induced protein with tetratricopeptide repeats 3(IFIT3), Radical S-adenosyl methionine domain containing 2(RSAD2), Interferon induced protein with tetratricopeptide repeats …

Witryna15 wrz 2004 · We found that HERC5 possesses ubiquitin ligase activity and requires the presence of the ubiquitin-conjugating enzyme UbcH5a for its activity. These data …

WitrynaHere, we identify HERC5 (HECT domain and RLD 5) as a specific binding protein of IRF3 by immunoprecipitation. Ectopic expression or knockdown of HERC5 could, respectively, enhance or impair IRF3-mediated gene expression. Mechanistically, HERC5 catalyzes the conjugation of ubiquitin-like protein ISG15 onto IRF3 (Lys193, -360, and -366), … port 8888 was already in useWitryna17 lis 2011 · Cysteine 994 of the HERC5 HECT domain is essential for this E3 ligase activity of HERC5 . Two reports have also identified HERC5 as an E3 ubiquitin ligase [15, 16]. HERC5 is ubiquitously expressed with the … irish kerry cheeseWitryna18 gru 2024 · Finally, we identified a HERC5/6 chimeric gene that arose from independent duplication in rodent and bat lineages and encodes for a conserved … port 8848 was already in useWitrynaHERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets. Proc Natl Acad Sci USA. 103, 10735-10740. Kroismayr, R, Baranyi, U, Stehlik, C, Dorfleutner, A, Binder, BR, and Lipp, J (2004). HERC5, a HECT E3 ubiquitin ligase tightly regulated in LPS activated endothelial cells. port 8889 was already in useWitrynaHERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral Immune Response. Mathieu NA, et al.Viruses, 2024 Jun 9. PMID 34207696, Free PMC Article … port 8989 was already in useWitrynaThis gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that … port 8887 is already in useWitrynaBy differential screening we isolated genes upregulated in inflammatory cytokine-stimulated human skin microvascular endothelial cells. One of these cDNAs encoded RCC1 (regulator of chromosome condensation 1)-like repeats and a HECT (homologous to E6-AP C-terminus) domain, representing a member of the HERC (HECT and … port 88 is used for