WebHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a constitutively-expressed … Web6 de jul. de 2024 · Introduction. Angiogenesis refers to the process of de novo formation of blood vessels, which takes place from already existing vessels. It is required for correct delivery of nutrients and oxygen to—as well as removal of waste products of aerobic metabolism from—newly generated cells, such as physiologically, during tissue growth, …
Frontiers Exploration and identification of six novel ferroptosis ...
Web29 de jan. de 2024 · Request PDF COMMD10 inhibits HIF1α/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu-Fe balance in hepatocellular carcinoma Background & Aims As an essential trace element ... Web1 de fev. de 2024 · Ferroptosis and pyroptosis are new types of cell death. Activation of ferroptosis-related pathways not only promotes cell death of general tumor cells but … pioneer sc 91 review
Pharmacological inhibition of sphingolipid synthesis reduces ...
Web9 de abr. de 2024 · Ferroptosis is a novel form of regulated cell death. Accumulation of lipid peroxidation and intracellular FE/FE 2+ are key determinants of ferroptosis [ 36 ]. Our findings support that PMAN has the ability to alleviate ferroptosis in tumor cells, and HIF-1α is shown to be a key protective factor for tumor cells to resist ferroptosis under hypoxia. WebNational Center for Biotechnology Information Web13 de jan. de 2024 · Ferroptosis is a regulated cell death nexus linking metabolism, redox biology and diseases including cancer. The aim of the present study was to identify a ferroptosis-related gene prognostic signature for stomach adenocarcinoma (STAD) by systematic analysis of transcriptional profiles from The Cancer Genome Atlas (TCGA), … pioneer sc-95