2024 Klf2 endothelial cell

Klf2 endothelial cell

Author: ngra

August undefined, 2024

WebMar 31, 2024 · Gimbrone MA Jr, Garcia-Cardena G. Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis. Circ Res. 2016 Feb 19;118(4):620-36. doi: 10.1161/CIRCRESAHA.115.306301. WebTzima et al showed that platelet and endothelial cell adhesion molecule-1 (PECAM-1, also called CD31), vascular ... showed significantly less induction of KLF2 expression than ciliated cells in the embryonic heart. 92 Primary cilia on ECs protrude into the vascular lumen and are molecular switches for Ca 2+ and NO signalling. 93 The ...

Tumor Necrosis Factor Alpha-Mediated Reduction of KLF2 Is …

WebAug 7, 2024 · KLF2 regulates a network of genes that maintain vascular barrier integrity and confer EC quiescence, resulting in an anti-inflammatory, anti-thrombotic EC phenotype ( Dekker et al., 2006 ). Interestingly, high LSS suppresses EC glucose uptake, glycolysis and mitochondrial respiration via a KLF2-dependent mechanism ( Doddaballapur et al., 2015 ). WebWe recently reported the observation that KLF2 is a potent inducer of endothelial nitric oxide synthase, a key regulator of vessel biology. 16 To gain greater insight into additional … empower healthcare services

KLF2+ stemness maintains human mesenchymal stem cells in …

WebApr 9, 2013 · A new study reported in this issue of Cell Research revealed that KLF2, a transcription factor that negatively regulates endothelial functions, is also a substrate of … WebJun 23, 2024 · The protein levels of endothelial markers (PECAM1 [platelet endothelial cell] adhesion molecule-1 and VE-Cadherin) were reduced in human umbilical vein ECs (HUVECs) with KLF2 knockdown. The … WebOur studies suggest that endothelial Klf2 is expressed in response to fluid shear forces and is required for vascular hemodynamic regulation during development, but they do not … draw length compound bow

Tumor Necrosis Factor Alpha-Mediated Reduction of KLF2 Is …

Krüppel-Like Factor 2 Is Required for Normal Mouse Cardiac

WebMay 5, 2004 · Overexpression of KLF2 in umbilical vein endothelial cells robustly induced endothelial nitric oxide synthase expression and total enzymatic activity. In addition, KLF2 … WebApr 30, 2024 · Expression of KLF2 by endothelial cells is known to exert protective effects against atherosclerosis, however OSS greatly reduces expression of KLF2 at both the mRNA and protein levels. To determine whether GPR30 plays a role in OSS-induced downregulation of KLF2, HAECs were exposed to OSS (± 5 dyn/cm 2 ) in the presence or absence of 5 and … empower health solutions provider portal draw level with crossword

"WebApr 11, 2024 · To systematically dissect the transcriptomic differences between homeostasis and chronic dry skin at the single-cell level, we carried out scRNA-seq on two biological mixed samples from each group, and each mixed sample contained three mice (Fig. 1 A).After quality control, we obtained 18,578 cells in the AEW groups and 24,160 … " - Klf2 endothelial cell

Klf2 endothelial cell

Therapeutic potential of KLF2-induced exosomal microRNAs in

WebNov 13, 2024 · Krüppel-like Factor 2 (KLF2) is an important indicator of the stemness of human MSCs (hMSCs) and as early vascularization is also critical for bone regeneration, we used KLF2 as a novel in vitro marker for MSCs and investigated the angiogenesis and osteogenesis between KLF2 + MSCs and endothelial cells (ECs). WebMay 12, 2024 · Endothelial cell MEKK3-KLF2/4 signaling can be activated by both fluid shear forces and inflammatory mediators, and it plays roles in cardiovascular development and disease that have been linked to both stimuli.

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WebThe endothelium lines the luminal surface of the arterial wall and is in direct contact with blood flow. The pulsatile shear stress (PS) at straight parts of arteries maintains endothelial homeostasis, whereas oscillatory shear stress (OS) at bifurcations and curvatures impairs endothelial function. WebMay 25, 2024 · Kruppel-like factor 2 (KLF2) is a laminar flow-inducible transcription factor primarily expressed by endothelial cells that play an important role in the regulation of endothelial function [3,4]. Studies have shown that KLF2 induces eNOS expression and increases NO production in cultured human umbilical vein endothelial cells (HUVECs) and …

WebFeb 23, 2024 · Inducible endothelial-specific deletion of Klf2 and/or Klf4 reveals that a single allele of either gene is sufficient for survival, but absence of both (EC-DKO) results … WebMar 13, 2024 · The AMPK/KLF2 axis activates the expression of endothelial nitric oxide (NO) synthase (eNOS) in endothelial cells, subsequently promoting the release of vasodilator-NO (21). Endothelial cell-derived NO serves key roles in vasodilation, inhibition of platelet aggregation and reduction of leukocyte adhesion, and as an antioxidant (22).

WebLung Kruppel-like factor/KLF2 is highly expressed in the vascular endothelium (17). Systemic knockout of KLF2 results in embryonic death and abnormal vessel formation (17, 18). However, our understanding of the function and targets of KLF2 in endothelial biology have been lacking to date. We recently identiﬁed KLF2 as a novel transcriptional reg- WebApr 13, 2024 · For instance, activation of the MEK5/ERK5/KLF2 pathway by fluid shear stress in endothelial cells has recently been shown to require mROS production (Coon et al., J Cell Biol (2024) 221 (7): e202409144). By contrast, Abe’s group observed that H2O2 stimulation could enhance ERK5 phosphorylation but inhibited ERK5-mediated gene expression (e.g ...

WebJul 22, 2010 · KLF2 is a shear stress-induced factor that confers antiinflammatory and antithrombotic properties to the vascular EC. 15–21 However, despite the acknowledged importance of the endothelium in determining vascular barrier function, studies assessing the role of KLF2 (or any other member of this gene family) have not been reported.

WebJan 1, 2024 · Background & Aims. The transcription factor Krüppel-like factor 2 (KLF2), inducible by simvastatin, confers endothelial vasoprotection. Considering recent data … empower health insurance loginLung buds removed from KLF2-deficient mouse embryos and cultured from normal tracheobronchial trees. In order to circumvent embryonic lethality usually observed in KLF2-deficient embryos, KLF2 homozygous null mouse embryonic stem cells were constructed and used to produce chimeric animals. These KLF2-deficient embryonic stem cells contribute significantly to development of skeletal muscle, spleen, heart, liver, kidney, stomach, brain, uterus, testis, and … draw less than ogive for the following dataWebFeb 2, 2024 · KLF2 and KLF4 control endothelial identity and vascular integrity - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil. sharing sensitive information, make sure you’re on a federal empower health hawaiiWebNational Center for Biotechnology Information empower health referralWebMar 4, 2024 · While endothelial KLF2 and endothelium-derived KLF2-induced miRNAs have homoeostatic, anti-proliferative effect on vascular endothelial and smooth muscle cells, direct activation of KLF2 in ... draw level curvesWebFeb 18, 2024 · In human endothelial cells (ECs), acute inhibition of the HEG1-KRIT1 interaction by HKi2 increased KLF4 and KLF2 mRNA and protein levels, whereas a structurally similar inactive compound failed to do so. In zebrafish, HKi2 induced expression of klf2a in arterial and venous endothelium. empower health richland waWebNov 22, 2024 · Restoration of MAPK7 signaling abrogated these pathological effects in endothelial cells expressing miR-374b. Thus, our data suggest that the TGFβ-miR-374b-MAPK7 axis plays a key role in the induction of endothelial–mesenchymal transition during intimal hyperplasia and early lesion formation and might pose an interesting target for ... empower health screening