Mineralocorticoid receptor antagonists are diuretic drugs that work primarily on the kidneys. They decrease sodium reabsorption, which leads to increased water excretion by the kidneys. By regulating water excretion, mineralocorticoid receptor antagonists lower blood pressure and reduce fluid around … Meer weergeven An antimineralocorticoid, also known as a mineralocorticoid receptor antagonist (MRA or MCRA) or aldosterone antagonist, is a diuretic drug which antagonizes the action of aldosterone at Meer weergeven Increased urination is a commonly reported side effect, particularly during the initial phase following treatment initiation; this is … Meer weergeven When comparing the pharmacokinetic properties of spironolactone and eplerenone, it is clear that the two drugs differ. Spironolactone has … Meer weergeven The main goal of the identification of the first aldosterone antagonists, which happened during the 1950s, was to identify … Meer weergeven Aldosterone is a mineralocorticoid which is synthesized in the adrenal glands. When aldosterone is secreted from the adrenal glands, it binds to the mineralocorticoid receptor in the renal tubule cell and forms a complex. This complex enhances transcription of … Meer weergeven Spironolactone and Eplerenone competitively block the binding of aldosterone to the mineralocorticoid receptor and hindering the reabsorption of sodium and … Meer weergeven Members of this class in clinical use include: • Widespread use • Uncommon use (to date) Some drugs also have antimineralocorticoid … Meer weergeven WebMechanisms involved in mineralocorticoid-sensitive inflammation and fibrosis include the serum- and glucocorticoid-inducible kinase 1 (SGK1), which is genomically upregulated …
Mineralocorticoid 释义 柯林斯英语词典 - Collins Dictionary
WebThe mineralocorticoid receptor (or MR, MLR, MCR ), also known as the aldosterone receptor or nuclear receptor subfamily 3, group C, member 2, ( NR3C2) is a protein that in humans is encoded by the NR3C2 gene that is located on chromosome 4q31.1-31.2. [5] MR is a receptor with equal affinity for mineralocorticoids and glucocorticoids. Web17 jun. 2024 · Steroidal mineralocorticoid receptor antagonists (MRAs) such as spironolactone and eplerenone reduce mortality but remain under-prescribed due to the … heating catered food
Adverse Effects of Mineralocorticoid Receptor Antagonist …
Web19 sep. 2024 · Background The novel nonsteroidal mineralocorticoid receptor (MR) antagonist finerenone holds promise to be safe and efficient in the treatment of patients with heart failure and/or chronic kidney disease. However, its effects on vascular function remain elusive. Purpose The aim of this study was to determine the functional effect of selective … WebMineralocorticoid antagonists comprise a group of agents that antagonize the action of the endogenous mineralocorticoid, aldosterone, at its receptors. Aldosterone is of … Web15 jul. 2024 · Mineralocorticoid receptor (MR) antagonists, such as spironolactone and eplerenone, are currently used to treat hypertension and chronic heart failure. movies with the song time after time