Mouse asct2
NettetAlthough the human and mouse ASCT2 orthologs are 81% identical, a notable clustering of divergences occurs in two regions of ECL2 that are separated by a sequence that is highly conserved not only ... Nettet15. jul. 2024 · ASC amino acid transporter 2 (ASCT2), also known as solute linked carrier family 1 member A5 (SLC1A5) is a Na+-dependent glutamine/neutral amino acid …
Mouse asct2
Did you know?
NettetThe encoded protein, designated ASCT2, showed amino acid sequence similarity to the mammalian glutamate transporters (40–44% identity), Na + -dependent neutral amino acid transporter ASCT1 (57% identity; Arriza, J. L., Kavanaugh, M. P., Fairman, W. A., Wu, Y.-N., Murdoch, G. H., North, R. A., and Amara, S. G. (1993) J. Biol. Chem. 268, … NettetCompare Slc1a5 Mouse qPCR Template Standard (NM_009201) from OriGene Technologies on Biocompare.com. Welcome Guest. Sign In Register. Products. Popular Categories; ... ASCT2, ATBO, M7V1, M7VS1, R16, RDRC, Slc1a7; Primer Type Gene-specific Primers; Add to Compare List. OriGene Technologies. 9620 Medical Center …
NettetAlthough ASCT2 knockout mice do not display any neurological phenotypes, ASCT2 dysregulation does appear to be implicated in depression [91, 94]. In the chronic social defeat stress (CSDS) mouse model of depression, CSDS mice display overexpression of ASCT2, and improved social behaviours upon ASCT2 knockdown . NettetV-9302 is a competitive small molecule antagonist of transmembrane glutamine flux, that selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) with an IC50 value of 9.6 μM for inhibition of glutamine uptake in HEK-293 cells. V-9302 blocks Sodium-neutral AA transporter 2 (SNAT2, SLC38A2) and the large neutral AA transporter 1 …
Nettet5. feb. 2024 · These findings highlight a mechanism of T cell activation involving ASCT2-dependent integration of the T cell receptor signal and a metabolic signaling pathway. … Nettet15. mar. 2024 · The unique metabolic demand of cancer cells suggests a new therapeutic strategy targeting the metabolism in cancers. V9302 is a recently reported inhibitor of ASCT2 amino acid transporter which shows promising antitumor activity by blocking glutamine uptake.
NettetHowever, while ASCT2 band was detected at the molecular weight expected for the glycosylated form in HOG cells , Hs683 cells mainly expressed non-glycosylated forms of ASCT2 (Figure 7b). Consistently with this glycosylation pattern, peripheral co-localization of ASCT2 with β-catenin was detectable in HOG cells, but not in Hs683 cells ( Figure 7 c).
Nettet10. apr. 2024 · Mice bearing WCM12, WCM1262, WMC154, WCM1078, 22Rv1-WT and 22Rv1-LMD subcutaneous tumors were imaged with 18 F-rh-PSMA and 18 F-fluciclovine radioligand formulated in acetate buffered saline. imperial isb-24NettetASCT2 appears to be the major glutamine transporter in hepatoma cells and is thought to provide essential amino acids needed for tumor growth (3). Additional evidence … litchfield peter m mdNettet31. jul. 2024 · Analysis of ASCT2 function by shRNA knockdown showed HEC1A cells rely on ASCT2-mediated glutamine uptake, while Ishikawa cells have only a partial reliance … litchfield performing artsNettetCell Signaling Technology Inc mouse anti asct2 antibody Mouse Anti Asct2 Antibody, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars … imperial irrigation supply menifee caNettetSummary. ASCT2 is a ubiquitously expressed, broad-specificity, sodium-dependent neutral amino acid exchanger. Along with LAT1, a sodium-independent amino acid antiporter, … litchfield performance ukNettet29. jul. 2024 · Oh yes. I always play with mouse and keyboard, and it's very smooth. The problem is that some keys are bugged right now and don't do anything when assigned … litchfield phlebotomyNettetexist. We show here that ASCT2, a variant of transport system ASC, is strongly expressed in rat astroglia-rich primary cultures but not in neuron-rich primary cultures. The amino acid sequence of rat astroglial ASCT2 is 83% identical to that of mouse ASCT2. In Xenopus laevis oocytes expressing rat ASCT2, we observed high-affinity litchfield pet supply ct