Nis in thyroid
WebThe sodium-iodide symporter (NIS) is a member of the sodium/solute symporter family that actively transports iodide across the membrane of the thyroid follicular cells. In 1996, NIS mRNAs from rats 52 and humans 53 were isolated. The human gene (SLC5A5) maps to chromosome 19p13.2-p12. WebThe Sodium/Iodide Symporter (NIS) is responsible for the active transport of iodide into thyroid follicular cells. Differentiated thyroid carcinomas (DTCs) usually preserve the functional...
Nis in thyroid
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WebJul 1, 2001 · In addition to its key role in thyroid physiology, NIS-mediated iodide accumulation in the thyroid gland is a crucial prerequisite for diagnostic scintigraphic imaging as well as for the highly efficient radioiodine therapy of benign and malignant thyroid diseases. The purpose of this review is to summarize and discuss the current … WebMay 27, 1997 · NIS (Na + /I − symporter) is a key plasma membrane protein that catalyzes the active accumulation of iodide (I −) in the thyroid gland, a major step in the biosynthesis of thyroid hormones thyroxine (T 4) and tri-iodothyronine (T 3 ).
WebResults: NIS is highly expressed in the basolateral membranes of the majority of striated ducts, yet weakly expressed in few intercalated and excretory duct cells. The ratio of (123)I accumulation between parotid and submandibular glands is 2.38±0.19. WebThe rat thyroid model was then extrapolated to humans using human . in vitro . HTS data for NIS inhibition and the chemical specific hepatic clearance rate in humans. The overall species extrapolated PBPK-thyroid kinetics model can be used to predict dose-response (% drop in thyroid serum levels compared to homeostasis) relationships in humans.
WebJan 18, 2016 · Being a member of the solute carrier transporter (SLC5A5), NIS is an intrinsic plasma membrane glycoprotein that mediates active iodide transport in thyroid follicular cells. NIS mediated iodide ... WebNIS has the benefit of having both reporter gene and therapeutic functions, therefore, NIS gene transfer makes it possible to visualize, monitor, and treat tumors with suitable …
WebThe sodium/iodide symporter. Iodine is essential for the synthesis of the thyroid hormones thyroxine (T4) and triiodothyronine (T3). Iodide ions are taken up by the NIS, a basolateral transmembrane protein on the thyroid follicular cells that actively co-transports sodium and iodide ions into cells against a concentration gradient. 3 Iodide is then translocated …
WebPaneeraq Noahsen, “Thyroid function and autoimmunity among populations in Greenland with 10 and 20 years follow-up”. ... kan du tilmelde dig til [email protected] eller tlf. 361255. Sted: Ilisimatusarfik. Dato: 26/11/2024. Tidspunkt: 09:00. Facebook Twitter LinkedIn Email Om os. Grønlands Forskningsråd arbejder for at fremme forskning med ... fire ant nuptial flight seasonWebAn iodide transport defect, a result of impaired iodide transport by the NIS protein mechanism, is rare and is reflected in defective iodide transport in the thyroid, salivary gland, and gastric mucosa. 144,145 Some mutations in such patients produce reduced activity, and others completely inactivate NIS by preventing the protein from being ... fire ant lawn sprayWebJun 9, 2010 · It is well known that NIS expression in thyroid is regulated by the thyroid statuses mainly through thyroid stimulating hormone (TSH). Although NIS mRNA … essential toxicology pdf streptomycinWebThyroid hormone synthesis requires a variety of molecules in thyroid follicular cells, including sodium iodide symporter (NIS), which transports iodide into the cells, and thyroperoxidase (TPO), which oxidizes iodide into iodinium (I+) that in turn iodinates thyroglobulin (Tg) ( Figure 32.1) [1]. essential touch palmers greenWebThere are some mutations in the NIS DNA that cause hypothyroidism and thyroid dyshormonogenesis. Moreover, antibodies anti-NIS have been found in thyroid … fire ant nationWebJul 1, 2000 · NIS plays key roles in thyroid pathophysiology as the route by which iodide reaches the gland for thyroid hormone biosynthesis and as a means for diagnostic scintigraphic imaging and for radioiodide therapy in hyperthyroidism and thyroid cancer. fire ant nuptial flightWebRadioiodine therapy (RAI) is a standard and effective therapeutic approach for differentiated thyroid cancers (DTCs) based on the unique capacity for iodide uptake and accumulation of the thyroid gland through the Na+/I− symporter (NIS). However, around 5–15% of DTC patients may become refractory to radioiodine, which is associated with a worse prognosis. essential tracker ghostery