P50atf6
WebJan 30, 2004 · We reported that overexpression of CHOP or p50ATF6 (active form of ATF6) induces apoptosis in RAW 264.7 cells and COS-7 cells. 7 Expression of the transfected CHOP gene was barely detected in RAW ... WebNuclear immunoreactivity of ATF6, which has been demonstrated previously as p50ATF6 frag- ments (21), increased in wild-type cells from 2 h after the induction of ER stress by …
P50atf6
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WebApr 26, 2024 · Murine full-length cDNAs for Atf6 (p50Atf6), Atf4, Chop, Mzf1, Sp1, Jun, and Ets1 were then amplified by PCR using gene-specific primers (Online Resource 1, Table S1) and HotStar-HighFidelity Polymerase (Qiagen). The template for amplification of spliced Xbp1 was the plasmid TETO/CMV/pUC19-Xbp1 (obtained from Prof. T. Weaver, Cincinnati, … Web(p50ATF6) is produced.38 p50ATF6 active form is trans-ported to nucleus, and functions as transcriptional activator for ER stress-related genes.32,39 Four distinct ER stress …
WebConversion of ATF6 to p50ATF6 after ER stress. Primary cultured fibroblasts from PS1 knock-out (a) and PS1 mutation knock-in (b) mice were treated with 2 g/ml Tm for the … WebVEGF is associated with enhancement of p50ATF6 from 30 min up to 3 hr (Figure 2D), whereas Tm-treated HUVECs ex-hibited undetectable p90ATF6 levels from 2 to 4 hr that were associated with increasing quantities of p50ATF6 (Figure 2E), a pattern also reported in previous studies (Hong et al., 2004).
Web(ERSE) through which p50ATF6 exerts its activity (9–12). In parallel with ATF6, ER stress-inducing agents activate the IRE1 / proteins (15, 16). IRE1 is a ubiquitously ex-pressed ER type I transmembrane protein containing both a serine/threonine kinase module and an endoribonuclease do-main in its cytosolic region (15). Upon UPR activation, IRE1 WebNov 17, 2024 · P50ATF6 protein was highly expressed in the oocytes of large follicles. These results indicate that P50ATF6 expression is significantly increased in fully formed COC structures at M II (44 hours). These results demonstrated that most UPR signaling markers increased in COCs during IVM progression.
WebMar 26, 2008 · (p50ATF6). Similarly, activated IRE1 catalyzes removal of a small intron from the mRNA of the gene encoding X-box binding protein 1 (XBP1). This splicing event creates a translational frameshift in XBP1 mRNA to produce an active transcription factor. Active p50ATF6 and XBP1 subsequently bind to the ER stress
Web暨南大学,数字图书馆. 开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 swiss tech men\u0027s sweater fleece glovesWebThus, once p50ATF6 produced by ER stress-induced proteolysis is translocated into the nucleus, it can directly bind to ERSE and activate transcription of target genes in vivo as depicted in Fig. Fig.13. 13. We propose that the ER stress response factor (ERSF) binding to ERSE responsible for the mammalian UPR is a heterologous protein complex ... swiss tech men\u0027s winter coatshttp://www.obdtester.com/ford-ecu-update/f_series/5.0l/1996/F6TF-12A650-PD swiss tech microWebJan 31, 2024 · During EV-A71 infection, however, this p50ATF6 product was not detected in the nucleus, and its downstream target genes were not activated. We examined the role of … swiss tech men\u0027s travel pantWebp50ATF6 is a nuclear protein. p90ATF6 is a type II transmembrane glycoprotein with a hydro- phobic stretch in the middle of the molecule. Thus, the N-terminal half containing a basic … swiss tech men\u0027s wool socksWebNov 1, 1999 · In contrast, p50ATF6 is a soluble nuclear protein (Figures (Figures5 5 and and7). 7). When overexpressed, ATF6 mutants representing p50ATF6 were accumulated in the nucleus (Figure (Figure8) 8) and constitutively activated transcription of the GRP78 gene, leading to enhanced levels of GRP78 in the ER (Figure (Figure9). 9). We thus propose that ... swiss tech micro slimWebApr 9, 2015 · We observed induction of Atf6 (activating transcription factor 6, an endoplasmic reticulum (ER) stress response transcription factor) mRNA expression and … swiss tech model 31632