Phenylethynesulfonamide
Web1. jan 2024 · PES (2-phenylethynesulfonamide, pifithrin-μ, PFTμ) is an electrophilic compound that exhibits anticancer properties, protects against chemotherapy-induced … WebRole of this protein with respect to intracellular survival and multiplication of protozoan parasite like T. gondii remains to be examined. We find that T. gondii infection upregulates expression of host Hsp70. Hsp70 selective inhibitor 2-phenylethynesulfonamide (PES) attenuates intracellular T. gondii multiplication.
Phenylethynesulfonamide
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WebPifithrin-μ (10 μM) is a p53 inhibitor, which inhibits p53 binding to mitochondria by reducing its affinity to antiapoptotic proteins Bcl-xL and Bcl-2 but has no effect on p53-dependent transactivation, activity of caspases 2, 8, 9 and 10 in a cell-free system, or NF-κB-dependent transcription.Pifithrin-μ (PES) time- and dose-dependently reduces viability in A549 cells, … Web2-phenylethynesulfonamide (CHEBI:93704) is a benzenes (CHEBI:22712) Manual Xref Database LSM-4188: LINCS View more database links: ChEBI is part of the ELIXIR …
WebPifithrin-μ is an inhibitor of p53 binding and anti-apoptotic, which directly inhibits p53 binding to mitochondria as well as to Bcl-xL and Bcl-2 proteins. PFTμ rescues cells from lethal γ … WebFind at CymitQuimica all products linked to CAS 64984-31-2. Enter now to get more information
Web2-Phenylethynesulfonamide (PES) uncovers a necrotic process regulated by oxidative stress and p53. Biochem Pharmacol. , 91 (3), 301-311. Mattiolo, P ; Barbero-Farran, A ; Yuste, VJ … Web2-phenylethynesulfonamide: Canonical SMILES: C1=CC=C(C=C1)C#CS(=O)(=O)N: 运输条件: 蓝冰运输或根据您的需求运输。 一般建议: 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。
Web14. jan 2024 · Pifithrin-μ（10μM）是一种p53抑制剂，通过降低其对抗细胞凋亡蛋白Bcl-xL和Bcl-2的亲和力来抑制p53与线粒体的结合，但对p53依赖的反式激活，caspase的活性没有 …
Web2-chloro-1-methylpyridin-1-ium;2-(4-fluorophenyl)-N-methyl-2-oxo-N-phenylethanesulfonamide;2-(4-fluorophenyl)-N-methyl-N-phenylethynesulfonamide;methanesulfonyl chloride;N-methylaniline;methyl 4-fluorobenzoate;N-methyl-N-phenylmethanesulfonamide;iodide C60H63Cl2F3IN5O11S4 … bricklayer london ontarioWebNational Center for Biotechnology Information bricklayer macclesfieldWeb1. jan 2024 · The small molecule 2-phenylethynesulfonamide (PES) was originally identified as the inhibitor of p53 effects on the mitochondrial death pathway. In this report we … bricklayer local 5WebPifithrin-μ (10 μM) is a p53 inhibitor, which inhibits p53 binding to mitochondria by reducing its affinity to antiapoptotic proteins Bcl-xL and Bcl-2 but has no effect on p53-dependent … bricklayer lewishamWebPurpose: The aim of this work was to demonstrate the potentiation of 2-phenylethynesulfonamide (PES) at various combination treatments with MFH, using low … covid 19 survival rate with vaccineWebIn addition to its transactivational functions, p53 mediates apoptosis by binding with the anti-apoptotic proteins Bcl-xL and Bcl-2 at the mitochondrial surface. 1,2 Pifithrin-μ (PFT … bricklayer londonWebThe Hsp70 inhibitor 2-phenylethynesulfonamide inhibits replication and carcinogenicity of Epstein-Barr virus by inhibiting the molecular chaperone function of Hsp70. Cell Death Dis 9:734 (2024). PubMed: 29959331 brick layer logos