Spongistatin patents
WebSynthesis of spongistatin 2 employing a new route to the EF fragment† Helmut Kraus,a Antoine Français,a Matthew O'Brien,ab James Frost,a Alejandro Di´eguez-V ´azquez, a Alessandra Polara,a Nikla Baricordi,a Richard Horan,a Day-Shin Hsu,a Takashi Tsunodaa and Steven V. Ley*a An improved route to the EF fragment of the spongistatins has been … Web4 Oct 2006 · Abstract. A twenty year investigation of the South African marine sponge Spirastrella spinispirulifera (Carter, 1879) for antineoplastic constituents has now led to discovery of spongistatin 6 (1e) and 7 (2b) in 3.5 × 10 −7 % and 2.2 × 10 −7 % yields. Structural elucidations were based on detailed analyses of high field (400 and 500 MHz) …
Spongistatin patents
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WebThe design, synthesis, and biological evaluation of two diminutive forms of (+)-spongistatin 1, in conjunction with the development of a potentially general design strategy to simplify highly flexible macrocyclic molecules while maintaining biological activity, have been achieved. Examination of the solution conformations of (+)-spongistatin 1 revealed a … Web1 Jun 2009 · Enantioselective approaches to the construction of four complex building blocks of the structurally intricate marine macrolide known as spongistatin 1 are presented. The first phase of the synthetic effort relies on a practical approach to a desymmetrized, enantiomerically pure spiroketal ring system incorporating rings A and B. Concurrently, …
WebSpongistatin 1. 24 Spongistatin 1 is a noncompetitive inhibitor of the binding of [3H]vinblastine and [3H]dolastatin to tubulin, in contrast to competitive patterns obtained with vincristine versus [3H]vinblastine and with a stereoisomer of dolastatin 10 versus [3H]dolastatin 10. From: Medicinal Chemistry of Anticancer Drugs, 2008. Web1 Sep 2010 · Spongistatin 1 was applied in an orthotopic in vivo model of human pancreatic cancer. Spongistatin 1 significantly reduced tumor growth, which correlates with a strong apoptosis induction (DNA-fragmentation) and long-term effects on clonogenic survival of pancreatic tumor cells (L3.6pl) in vitro.
Web29 Feb 2008 · The mean GI50's of spongistatins 2, 3 and 6 were 8–10 × 10 −10 M. Spongistatin 1 at a dose of 10 μg/kg ip and spongistatin 4 at a dose of 5 μg/kg ip … Web1 Nov 2013 · Endostatin is a 20 kDa C-terminal fragment of type XVIII collagen (O’Reilly et al., 1997), a component of the basement membrane binds to the α5β1/αvβ3 integrin. It is the major fibronectin receptor for endothelial cells (Rehn et al., 2001, Wickström et al., 2002) and may block endothelial cell focal adhesions ( Wickström et al., 2002 ).
Web16 Jun 1997 · Patent number: 5883120 Type: Grant Filed: Jun 16, 1997 Date of Patent: Mar 16, 1999 Assignee: Arizona Board of Regents, a body corporate, acting on behalf of …
WebCONSTITUTION: Spongistatin 1 represented by formula having properties as follows: Colorless amorphous powder; melting point: 161 to 162°C; specific rotation: [α]D 22 … screen protector cutting machineWebSynthesis of the C-1-C-28 (ABCD) unit of Spongistatin 1 Organic Letters, 2003, 5, 4819, 2003 See publication Patents Preparation of substituted amides as RAF kinase inhibitors … screen protector cut to sizehttp://www-paterson.ch.cam.ac.uk/research1.html screen protector costWebResearch objectives and content The Spongistatins are a new class of naturally occurring marine metabolites (isolated from the marine sponges Spongia sp. and Spirastella sp. in the early 1970s), the structures of which have been recently disclosed. This … screen protector decrease sensitivityWebUse Espacenet patent search to check for published patent applications and registered patents. The database includes both worldwide UK patents and details about: owners filed documents... screen protector crackedWeb28 Aug 2008 · In a quest to develop an effective, scalable synthesis of (+)-spongistatin 1 ( 1 ), we devised a concise, third-generation scalable synthesis of (+)- 7, the requisite F-ring tetrahydropyran aldehyde, employing a proline-catalyzed cross-aldol reaction. screen protector computer privacyWebSynthesis of altohyrtin C (identical with spongistatin 2) and altohyrtin A (spongistatin 1) have defined the relative and absolute stereochemistry of the natural compounds 5 which is shown below ... screen protector deals