WebApr 13, 2024 · The drug interaction between the hybrid compound and imatinib was studied using CompuSyn software. Drug synergism was determined with the help of the combination index (Figure 2a; Table 1) and isobologram (Figure 2b). Co-treatment of human leukemia cells with the hybrid and imatinib had a synergistic effect at all concentrations … WebThe synergistic effect of inhibitors was calculated by using the combination index (CI). The CI, a quantification of the degree of inhibitor interactions based on the median-effect principle, was calculated as described previously by Chou and colleagues using the CompuSyn software (ComboSyn Inc., Paramus, NJ, USA) [ 18 ].
Synergistic cytotoxicity of Bcl-xL inhibitor, gossypol and ...
WebDec 1, 2024 · The unified theory of the median-effect equation (MEE) of the mass-action law (MAL) indicates that dose and effect are interchangeable, and all dose-effect curves can … WebSep 17, 2024 · Combination of CA3 and trametinib induced a significant synergistic effect in vitro (Combination Index <1). Regarding the in vivo experiment, combination therapy … rock house tettenhall
Analysis of drug combinations: current methodological landscape
WebSynergy of the fungicidal effect of selenium nanoparticles and chitosan was quantified by the combination index theorem of Chou–Talalay. ... More studies are warranted to understand the synergistic effect of the combination of Se and CS against the Candida biofilm. Materials and methods. Materials. Se pellets (Se, <5 mm, ≤99.999% trace ... WebThe synergistic effects of the combination therapy on the PI3K/Akt/mTOR pathway, apoptosis, and EMT were evident in ... that combination therapy with an AKT inhibitor … Web1 day ago · Recent studies have revealed that a combination of zero-valent iron (ZVI) and pyrite (FeS 2) can effectively remove (Cr(VI)) from water, but the reasons behind this synergistic effect are still unclear.Our batch experiments showed that dissolved oxygen (DO) is a critical factor in the improved removal of Cr(VI) by ZVI and pyrite. others images