Web12. apr 2024 · List of Abbreviations . Abbreviation Definition . ACE Angiotensin-converting enzyme ACTH Adrenocorticotropic hormone AE Adverse event AHF Acute heart failure syndrome ARB Angioten Web12. apr 2024 · The details of JASPER have been previously described. 16 A total of 534 hospitalized patients with HFpEF from 15 university or teaching hospitals were registered from November 2011 to March 2015. Patients with missing variables (n = 230) and an eGFR < 15 mL/min/1.73 m 2 at discharge (n = 31) were excluded.Finally, we selected 273 …
Natriuretic Peptides and Spironolactone Effect in TOPCAT
WebSimilar to other HFpEF trials, 26,27 the elderly patients included in our study were characterized – when compared to HFpEF patients aged <65 years – by the following: a higher prevalence of females (P=0.0001); the presence of comorbidities (obesity, P<0.001; hypertension, P<0.0001; CKD, P<0.0001); and a NYHA functional class of IV (P<0. Web11. jan 2024 · In addition, spironolactone decreased the absolute risk of hypokalemia (absolute risk difference for total population, -14%; 95% CI, -18% to -9%; p < 0001). The study authors also found that during 4-year follow-up, the absolute risk for AEs that prompted drug discontinuation was amplified in the lower eGFR categories, which suggested ... the corner pub and grill o\u0027fallon mo
Designing Future Clinical Trials in Heart Failure With Preserved ...
Web19. okt 2024 · Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome in which patients have signs and symptoms of HF as the result of high left ventric ... Desai AS, et al. Spironolactone Metabolites in TOPCAT - New Insights into Regional Variation. N Engl J Med 2024; 376:1690. Solomon SD, McMurray JJV, Anand IS, et al. Angiotensin ... WebAmong TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist Trial) participants, we performed latent-class analysis to identify HFpEF phenogroups based on standard clinical features and assessed differences in multiple biomarkers measured from frozen plasma; cardiac and arterial structure/function … Web25. apr 2016 · In the absence of alternative evidence-based therapies, spironolactone should be considered in HFpEF patients who meet TOPCAT inclusion criteria (HFpEF with prior … the corner pub and grill o\u0027fallon